I assume that each email address is set up for a different department? If you set the default email for each department, then replies should use the departments default email address.Admin Panel > Agents > DepartmentsSelect your Department and under Outgoing Email Settings, choose the outgoing email and template set. Also when posting in the forums its helpful to include information about your enviroment. I will copy and past @[deleted] 's standard reply for you:Please help us to help you by reading and following the posting guidelines located in this thread: Please read before requesting assistance. The more information you give us the better we will be able to assist you. Thank you.